Oprah Winfrey: After her birth, Oprah's mother traveled north, and Winfrey spent her first six years living with her grandmother.
Willie Nelson: Willie began performing music as a child growing up in Abbott, Texas. After his father died and his mother ran away, Nelson and his sister Bobbie were raised by their grandparents, who encouraged both children to play instruments.
Louis Armstrong: Born into extreme poverty in New Orleans, Armstrong was raised by his grandmother until the age of five.
Chris Jennings: Before his career in the NFL, Chris was living in Huntington, West Virginia, where he was raised by his grandparents, Rosa and Trellis Tyson.
Photos Courtesy of: insidesocial.com, eoprahwinfrey.com, salem-news.com,